Page 67 - CB1.3 Genetic Varation sciPAD
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CB 1.3 GENETIC VARIATION
USING KNOWLEDGE OF GENETICS
CDH1 Positive CDH1 Negative
CDH1 Negative
CDH1 Positive
CDH1 Positive
Not tested Not tested
Not tested Not tested
Unaffected or untested female
Unaffected or untested male
Deceased individual
CDH1 Negative
1. Describe how gene sequencing can be used for genetic screening.
2. Outline the relationship between stomach cancer and the Māori population.
3. Using nucleotide base sequences, describe the difference between a normal CDH1
sequence and a mutated CDH1 sequence.
4. Discuss how genetic screening can be used to improve the health outcomes in Māori
families with the mutated CDH1 gene.
5. Suggest a reason why the whānau members found at the top of the pedigree chart were
not tested.
6. Use the pedigree chart to describe why knowledge of whakapapa plays an important
part in screening for the CDH1 mutation.
Unchecked Sample Pages
For Review Purposes Only - Photocopying Prohibited
www.scipad.co.nz
